Local and substrate-specific S-palmitoylation determines subcellular localization of Gαo

How palmitoylated proteins specifically localize is not fully understood. Here, authors created the SwissKASH assay to visualize S-palmitoylation in cells and uncovered a striking substrate selectivity of acyltransferases at the core of this process.

Bibliographic Details
Published in:Nature Communications
Main Authors: Gonzalo P. Solis, Arghavan Kazemzadeh, Laurence Abrami, Jana Valnohova, Cecilia Alvarez, F. Gisou van der Goot, Vladimir L. Katanaev
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Online Access:https://doi.org/10.1038/s41467-022-29685-8