Targeting the membrane-proximal C2-set domain of CD33 for improved CAR T cell therapy

Current CD33-targeted immunotherapies typically recognize the membrane-distal V-set domain of CD33. Here, we show that decreasing the distance between T cell and leukemia cell membrane increases the efficacy of CD33 chimeric antigen receptor (CAR) T cells. We therefore generated and optimized second...

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Bibliographic Details

Published in:	Molecular Therapy: Oncology
Main Authors:	Salvatore Fiorenza, Sheryl Y.T. Lim, George S. Laszlo, Erik L. Kimble, Tinh-Doan Phi, Margaret C. Lunn-Halbert, Delaney R. Kirchmeier, Jenny Huo, Hans-Peter Kiem, Cameron J. Turtle, Roland B. Walter
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	MT: Novel therapeutic targets and biomarker development Special Issue acute myeloid leukemia AML adoptive cell therapy CD33 chimeric antigen receptor
Online Access:	http://www.sciencedirect.com/science/article/pii/S2950329924000961