Poly(A)-DG: A deep-learning-based domain generalization method to identify cross-species Poly(A) signal without prior knowledge from target species.

In eukaryotes, polyadenylation (poly(A)) is an essential process during mRNA maturation. Identifying the cis-determinants of poly(A) signal (PAS) on the DNA sequence is the key to understand the mechanism of translation regulation and mRNA metabolism. Although machine learning methods were widely us...

Full description

Bibliographic Details

Published in:	PLoS Computational Biology
Main Authors:	Yumin Zheng, Haohan Wang, Yang Zhang, Xin Gao, Eric P Xing, Min Xu
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2020-11-01
Online Access:	https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008297&type=printable