Fufang Duzhong Jiangu granule (FFDZ) ameliorates osteoarthritis development through maintaining subchondral bone homeostasis

IntroductionOsteoarthritis (OA) is a widespread joint disorder predominantly marked by cartilage degeneration and the hardening of subchondral bone, with a lack of disease-modifying drugs for OA treatment. Fufang Duzhong Jiangu granule (FFDZ), a Chinese medicine, has demonstrated efficacy and safety...

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Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Houfu Ling, Jianbo Xu, Qinghe Zeng, Zhen Fang, Liangyan Cheng, Wenhua Yuan, Jiali Chen, Yuliang Huang, Songfeng Hu, Hongting Jin, Peijian Tong, Ke Lu, Pinger Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Subjects:	subchondral bone homeostasis mesenchymal stem cell TGF-β signaling osteoarthritis Fufang Duzhong Jiangu granule
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1610007/full