Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy

Gene therapy would greatly benefit from a method to regulate therapeutic gene expression temporally. Riboswitches are small RNA elements that have been studied for their potential use in turning transgene expression on or off by ligand binding. We compared several tetracycline and toyocamycin-induci...

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Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	Reetta A. E. Eriksson, Tiina Nieminen, Lionel Galibert, Sanna K. Peltola, Petra Tikkanen, Piia Käyhty, Hanna M. Leinonen, Igor Oruetxebarria, Saana Lepola, Anniina J. Valkama, Eevi M. Lipponen, Hanna P. Lesch, Seppo Ylä-Herttuala, Kari J. Airenne
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Subjects:	riboswitch ON-switch gene therapy AAV (adeno-associated virus) VEGF-B tetracycline
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2022.1052318/full