Optimized riboswitch-regulated AAV vector for VEGF-B gene therapy

Gene therapy would greatly benefit from a method to regulate therapeutic gene expression temporally. Riboswitches are small RNA elements that have been studied for their potential use in turning transgene expression on or off by ligand binding. We compared several tetracycline and toyocamycin-induci...

書誌詳細
出版年:	Frontiers in Medicine
主要な著者:	Reetta A. E. Eriksson, Tiina Nieminen, Lionel Galibert, Sanna K. Peltola, Petra Tikkanen, Piia Käyhty, Hanna M. Leinonen, Igor Oruetxebarria, Saana Lepola, Anniina J. Valkama, Eevi M. Lipponen, Hanna P. Lesch, Seppo Ylä-Herttuala, Kari J. Airenne
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2022-12-01
主題:	riboswitch ON-switch gene therapy AAV (adeno-associated virus) VEGF-B tetracycline
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fmed.2022.1052318/full

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