Proteomic Analysis of Niemann-Pick Type C Hepatocytes Reveals Potential Therapeutic Targets for Liver Damage

Niemann-Pick type C disease (NPCD) is a lysosomal storage disorder caused by mutations in the <i>NPC1</i> gene. The most affected tissues are the central nervous system and liver, and while significant efforts have been made to understand its neurological component, the pathophysiology o...

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Bibliographic Details

Published in:	Cells
Main Authors:	Elisa Balboa, Tamara Marín, Juan Esteban Oyarzún, Pablo S. Contreras, Robert Hardt, Thea van den Bosch, Alejandra R. Alvarez, Boris Rebolledo-Jaramillo, Andres D. Klein, Dominic Winter, Silvana Zanlungo
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	liver damage Niemann Pick type C disease lysosomal storage disorder proteomic analysis mass spectrometry
Online Access:	https://www.mdpi.com/2073-4409/10/8/2159