Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function

Summary: The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood. Mature AgRP(83-132) has distinct residues for melanocortin receptor binding and heparan sulfate interactions. Here, we show...

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Bibliographic Details

Published in:	iScience
Main Authors:	Jihuan Chen, Valerie Chen, Tomoya Kawamura, Ivy Hoang, Yang Yang, Ashley Tess Wong, Ryan McBride, Vez Repunte-Canonigo, Glenn L. Millhauser, Pietro Paolo Sanna
Format:	Article
Language:	English
Published:	Elsevier 2019-12-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004219304420