Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling

The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maint...

詳細記述

書誌詳細

出版年:	Nature Communications
主要な著者:	Amy K. Rines, Hsiang-Chun Chang, Rongxue Wu, Tatsuya Sato, Arineh Khechaduri, Hidemichi Kouzu, Jason Shapiro, Meng Shang, Michael A. Burke, Eltyeb Abdelwahid, Xinghang Jiang, Chunlei Chen, Tenley A. Rawlings, Gary D. Lopaschuk, Paul T. Schumacker, E. Dale Abel, Hossein Ardehali
フォーマット:	論文
言語:	英語
出版事項:	Nature Portfolio 2017-01-01
オンライン･アクセス:	https://doi.org/10.1038/ncomms14095