Melatonin/Nrf2/NLRP3 Connection in Mouse Heart Mitochondria during Aging

Aging is a major risk for cardiovascular diseases (CVD). Age-related disorders include oxidative stress, mitochondria dysfunction, and exacerbation of the NF-κB/NLRP3 innate immune response pathways. Some of the molecular mechanisms underlying these processes, however, remain unclear. This study tes...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Marisol Fernández-Ortiz, Ramy K. A. Sayed, José Fernández-Martínez, Antonia Cionfrini, Paula Aranda-Martínez, Germaine Escames, Tomás de Haro, Darío Acuña-Castroviejo
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Subjects:	melatonin mitochondria NLRP3 inflammasome Nrf2 heart ultrastructure apoptosis
Online Access:	https://www.mdpi.com/2076-3921/9/12/1187