TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis

BackgroundDuring endotoxemia, immune activation rapidly increases energy needs. To meet these demands, white adipose tissue (WAT) mobilizes fatty acids through lipolysis. While fatty acids serve as energy-dense substrates, they also act as precursors for lipid mediators, including prostaglandins (PG...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Miguel Chirivi, Ursula Abou-Rjeileh, Madison Myers, Jair Parales-Giron, Lynn Worden, Adam L. Lock, G. Andres Contreras
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Subjects:	lipolysis prostaglandins adipocytes COX endotoxemia adipose tissue
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1591210/full