Repeated clinical malaria episodes are associated with modification of the immune system in children

Abstract Background There are over 200 million reported cases of malaria each year, and most children living in endemic areas will experience multiple episodes of clinical disease before puberty. We set out to understand how frequent clinical malaria, which elicits a strong inflammatory response, af...

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Bibliographic Details

Published in:	BMC Medicine
Main Authors:	Yaw Bediako, Rhys Adams, Adam J. Reid, John Joseph Valletta, Francis M. Ndungu, Jan Sodenkamp, Jedidah Mwacharo, Joyce Mwongeli Ngoi, Domtila Kimani, Oscar Kai, Juliana Wambua, George Nyangweso, Etienne P. de Villiers, Mandy Sanders, Magda Ewa Lotkowska, Jing-Wen Lin, Sarah Manni, John W. G. Addy, Mario Recker, Chris Newbold, Matthew Berriman, Philip Bejon, Kevin Marsh, Jean Langhorne
Format:	Article
Language:	English
Published:	BMC 2019-03-01
Subjects:	Malaria Systems immunology Immune activation
Online Access:	http://link.springer.com/article/10.1186/s12916-019-1292-y