Design and Characterization of Inhibitors of Cell-Mediated Degradation of APOBEC3G That Decrease HIV-1 Infectivity

The cytoplasmic human Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3 or A3) cytidine deaminases G and F (A3G and A3F) can block the spread of human immunodeficiency virus (HIV). HIV counteracts this cell-intrinsic defense through a viral protein called viral infectivity f...

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Bibliographic Details

Published in:	Viruses
Main Authors:	Aubrey M. Sawyer, Cristina C. Vaca, Neha Malik, Isabelle Clerc, Joshua Craft, Hannah Hudson, Gaël K. Scholtés, Gary E. Schiltz, Meejeon Roh, Chisu Song, Richard T. D’Aquila
Format:	Article
Language:	English
Published:	MDPI AG 2025-04-01
Subjects:	APOBEC3G APOBEC3F Vif HIV HIV-1 HIV cure research
Online Access:	https://www.mdpi.com/1999-4915/17/4/514