Identification of non-charged 7.44 analogs interacting with the NHR2 domain of RUNX1-ETO with improved antiproliferative effect in RUNX-ETO positive cells

Abstract The RUNX1/ETO fusion protein is a chimeric transcription factor in acute myeloid leukemia (AML) created by chromosomal translocation t(8;21)(q22;q22). t(8;21) abnormality is associated with 12% of de novo AML cases and up to 40% in the AML subtype M2. Previously, we identified the small-mol...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Mohanraj Gopalswamy, David Bickel, Niklas Dienstbier, Jia-Wey Tu, Melina Vogt, Stephan Schott-Verdugo, Sanil Bhatia, Manuel Etzkorn, Holger Gohlke
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-05-01
Subjects:	Acute myeloid leukemia T(8;21) Protein-protein interaction inhibitor Ligand-based virtual screening Cellular assay Biophysical experiment
Online Access:	https://doi.org/10.1038/s41598-025-02422-z