Identification of non-charged 7.44 analogs interacting with the NHR2 domain of RUNX1-ETO with improved antiproliferative effect in RUNX-ETO positive cells

Abstract The RUNX1/ETO fusion protein is a chimeric transcription factor in acute myeloid leukemia (AML) created by chromosomal translocation t(8;21)(q22;q22). t(8;21) abnormality is associated with 12% of de novo AML cases and up to 40% in the AML subtype M2. Previously, we identified the small-mol...

詳細記述

書誌詳細

出版年:	Scientific Reports
主要な著者:	Mohanraj Gopalswamy, David Bickel, Niklas Dienstbier, Jia-Wey Tu, Melina Vogt, Stephan Schott-Verdugo, Sanil Bhatia, Manuel Etzkorn, Holger Gohlke
フォーマット:	論文
言語:	英語
出版事項:	Nature Portfolio 2025-05-01
主題:	Acute myeloid leukemia T(8;21) Protein-protein interaction inhibitor Ligand-based virtual screening Cellular assay Biophysical experiment
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-02422-z