A Piezo1/KLF15/IL-6 axis mediates immobilization-induced muscle atrophy

Although immobility is a common cause of muscle atrophy, the mechanism underlying this causality is unclear. We here show that Krüppel-like factor 15 (KLF15) and IL-6 are upregulated in skeletal muscle of limb-immobilized mice and that mice with KLF15 deficiency in skeletal muscle or with systemic I...

詳細記述

書誌詳細

出版年:	The Journal of Clinical Investigation
主要な著者:	Yu Hirata, Kazuhiro Nomura, Daisuke Kato, Yoshihisa Tachibana, Takahiro Niikura, Kana Uchiyama, Tetsuya Hosooka, Tomoaki Fukui, Keisuke Oe, Ryosuke Kuroda, Yuji Hara, Takahiro Adachi, Koji Shibasaki, Hiroaki Wake, Wataru Ogawa
フォーマット:	論文
言語:	英語
出版事項:	American Society for Clinical Investigation 2022-05-01
主題:	Metabolism Muscle biology
オンライン･アクセス:	https://doi.org/10.1172/JCI154611