Incorporating single-arm studies in meta-analysis of randomised controlled trials: a simulation study

Abstract Background Use of real world data (RWD) from non-randomised studies (e.g. single-arm studies) is increasingly being explored to overcome issues associated with data from randomised controlled trials (RCTs). We aimed to compare methods for pairwise meta-analysis of RCTs and single-arm studie...

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Bibliographic Details
Published in:BMC Medical Research Methodology
Main Authors: Janharpreet Singh, Keith R. Abrams, Sylwia Bujkiewicz
Format: Article
Language:English
Published: BMC 2021-06-01
Subjects:
Evidence synthesis
Real world data
Single-arm studies
Bayesian hierarchical methods
Meta-analysis
Arm-based methods
Online Access:https://doi.org/10.1186/s12874-021-01301-1

Internet

https://doi.org/10.1186/s12874-021-01301-1

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