Discovery of bis-thiourea derivatives as potent tyrosinase inhibitors: combined experimental and computational study

Tyrosinase, a key enzyme in melanin synthesis, serves as a primary target for developing depigmenting agents. The search for novel tyrosinase inhibitors is needed due to the adverse effects of current inhibitors. This study evaluated 16 bis-thiourea derivatives using in vitro and in silico methods,...

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Bibliographic Details

Published in:	Journal of Enzyme Inhibition and Medicinal Chemistry
Main Authors:	Sahachai Sabuakham, Sutita Nasoontorn, Napat Nuramrum, Atit Silsirivanit, Thanyada Rungrotmongkol, Ratchanok Pingaew, Panupong Mahalapbutr
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Bis-thioureas computational biology molecular docking molecular dynamics simulations tyrosinase
Online Access:	https://www.tandfonline.com/doi/10.1080/14756366.2025.2518195