Development of Neutralization Breadth against Diverse HIV‐1 by Increasing Ab–Ag Interface on V2

Abstract Understanding maturation pathways of broadly neutralizing antibodies (bnAbs) against HIV‐1 can be highly informative for HIV‐1 vaccine development. A lineage of J038 bnAbs is now obtained from a long‐term SHIV‐infected macaque. J038 neutralizes 54% of global circulating HIV‐1 strains. Its b...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Nan Gao, Yanxin Gai, Lina Meng, Chu Wang, Wei Wang, Xiaojun Li, Tiejun Gu, Mark K. Louder, Nicole A. Doria‐Rose, Kevin Wiehe, Alexandra F. Nazzari, Adam S. Olia, Jason Gorman, Reda Rawi, Wenmin Wu, Clayton Smith, Htet Khant, Natalia de Val, Bin Yu, Junhong Luo, Haitao Niu, Yaroslav Tsybovsky, Huaxin Liao, Thomas B. Kepler, Peter D. Kwong, John R. Mascola, Chuan Qin, Tongqing Zhou, Xianghui Yu, Feng Gao
Format:	Article
Language:	English
Published:	Wiley 2022-05-01
Subjects:	antibody evolution broadly neutralizing antibodies humoral immunity nonhuman primates simian/human immunodeficiency virus virus variation
Online Access:	https://doi.org/10.1002/advs.202200063