Extraction optimization and reactivity of 7α-acetoxy-6β-hydroxyroyleanone and ability of its derivatives to modulate PKC isoforms

Abstract Protein kinase C is a family of kinases that play important roles in carcinogenesis. Medicinal plants from Plectranthus spp. (Lamiaceae) are a well-known source of interesting abietanes, such as 7α-acetoxy-6β-hydroxyroyleanone (Roy). This study aimed to extract and isolate Roy from P. grand...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Vera M. S. Isca, Gabrielle Bangay, Salvatore Princiotto, Lucília Saraíva, Daniel J. V. A. dos Santos, Alfonso T. García-Sosa, Patrícia Rijo
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-07-01
Online Access:	https://doi.org/10.1038/s41598-024-67384-0