ISR mRNAs as potential blood biomarkers in patients with vanishing white matter

Vanishing white matter (VWM) is a leukodystrophy caused by bi-allelic pathogenic variants in the eukaryotic initiation factor 2B (eIF2B). eIF2B orchestrates the integrated stress response (ISR), a physiological response to cellular stress. In VWM brain, the ISR is deregulated. The degree of ISR dere...

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Bibliographic Details

Published in:	Brain Disorders
Main Authors:	Ellen Oudejans, Gemma van Rooijen-van Leeuwen, Asako Takanohashi, Sophie van der Sluis, Truus E.M. Abbink, Adeline L. Vanderver, Marjo S. van der Knaap
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Subjects:	Vanishing white matter Integrated stress response NanoString Biomarker
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666459323000380