Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice

Summary: Cellular cholesterol is regulated by at least two transcriptional mechanisms involving sterol-regulatory-element-binding proteins (SREBPs) and liver X receptors (LXRs). Although SREBP and LXR pathways are the predominant mechanisms that sense cholesterol in the endoplasmic reticulum and nuc...

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Bibliographic Details

Published in:	iScience
Main Authors:	George D. Dalton, Seh-Hoon Oh, Linda Tang, Stephanie Zhang, Amanda L. Brown, Venkateshwari Varadharajan, Camelia Baleanu-Gogonea, Valentin Gogonea, Preeti Pathak, J. Mark Brown, Anna Mae Diehl
Format:	Article
Language:	English
Published:	Elsevier 2021-09-01
Subjects:	Lipid Molecular physiology Molecular biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004221010579