Pembrolizumab Combined With Neoadjuvant Chemotherapy Versus Neoadjuvant Chemoradiotherapy Followed by Surgery for Locally Advanced Oesophageal Squamous Cell Carcinoma: Protocol for a Multicentre, Prospective, Randomized-Controlled, Phase III Clinical Study (Keystone-002)

BackgroundTo compare the efficacy and safety of pembrolizumab combined with neoadjuvant chemotherapy (neoCT) versus neoadjuvant chemoradiotherapy (neoCRT) followed by surgery for locally advanced resectable oesophageal squamous cell carcinoma (ESCC).MethodsThis study is a multicentre, prospective, r...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Xiaobin Shang, Wencheng Zhang, Gang Zhao, Fei Liang, Chen Zhang, Jie Yue, Xiaofeng Duan, Zhao Ma, Chuangui Chen, Qingsong Pang, Weihong Zhang, Liang Liu, Xiubao Ren, Bin Meng, Peng Zhang, Yegang Ma, Lin Zhang, Hecheng Li, Xiaozheng Kang, Yin Li, Hongjing Jiang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-03-01
Subjects:	oesophageal cancer (EC) neoadjuvant therapy immunotherapy efficacy event-free survival (EFS)
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.831345/full