Efficient and highly reproducible production of red blood cell-derived extracellular vesicle mimetics for the loading and delivery of RNA molecules

Abstract Extracellular vesicles (EVs) are promising natural nanocarriers for the delivery of therapeutic agents. As with any other kind of cell, red blood cells (RBCs) produce a limited number of EVs under physiological and pathological conditions. Thus, RBC-derived extracellular vesicles (RBCEVs) h...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Sara Biagiotti, Barbara Canonico, Mattia Tiboni, Faiza Abbas, Elena Perla, Mariele Montanari, Michela Battistelli, Stefano Papa, Luca Casettari, Luigia Rossi, Michele Guescini, Mauro Magnani
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-06-01
Subjects:	Extracellular vesicles RBC-derived extracellular vesicles EV engineering Drug delivery miRNAs RNA therapy
Online Access:	https://doi.org/10.1038/s41598-024-65623-y