Reprogrammed CD8<sup>+</sup> T-Cells Isolated from the Mouse Spleen Increase the Number of Immune Cells with Antitumor Activity and Decrease the Amount of Cancer Stem Cells

We have developed an approach to reprogramming immune cells by inhibiting the MAPK/ERK pathway through MEKi and the PD-1/PD-L1 immune checkpoint signaling pathway. We hypothesized that reprogramming of spleen CD8<sup>+</sup> T-cells could also create a population of immune cells with hig...

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Bibliographic Details
Published in:Medical Sciences Forum
Main Authors: Evgenii G. Skurikhin, Olga Pershina, Mariia Zhukova, Angelina Pakhomova, Natalia Ermakova, Darius Widera, Edgar Pan, Lubov Sandrikina, Lena Kogai, Nikolai Kushlinskii, Sergey Morozov, Aslan Kubatiev, Alexander Dygai
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Subjects:
reprogrammed spleen CD8<sup>+</sup> T-cells
Lewis lung carcinoma
cancer stem cell
CD8<sup>+</sup> and CD4<sup>+</sup> T-cells
antimetastatic activity
Online Access:https://www.mdpi.com/2673-9992/21/1/40

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https://www.mdpi.com/2673-9992/21/1/40

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