Ataxin-3, The Spinocerebellar Ataxia Type 3 Neurodegenerative Disorder Protein, Affects Mast Cell Functions

Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph Disease, is a progressive neurodegenerative disorder characterized by loss of neuronal matter due to the expansion of the CAG repeat in the ATXN3/MJD1 gene and subsequent ataxin-3 protein. Although the underlying pathogenic protein e...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Anna S. Sowa, Eva Haas, Jeannette Hübener-Schmid, Axel Lorentz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-04-01
Subjects:	ataxin-3 MJD SCA3 mast cell cytokine neurodegeneration
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.870966/full