Blockade of the lncRNA-DOT1L-LAMP5 axis enhances autophagy and promotes degradation of MLL fusion proteins

Abstract Background Mixed-lineage leukemia (MLL) fusion gene caused by chromosomal rearrangement is a dominant oncogenic driver in leukemia. Due to having diverse MLL rearrangements and complex characteristics, MLL leukemia treated by currently available strategies is frequently associated with a po...

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Bibliographic Details

Published in:	Experimental Hematology & Oncology
Main Authors:	Tian-Qi Chen, Heng-Jing Huang, Shun-Xin Zhu, Xiao-Tong Chen, Ke-Jia Pu, Dan Wang, Yan An, Jun-Yi Lian, Yu-Meng Sun, Yue-Qin Chen, Wen-Tao Wang
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Subjects:	lncRNA LAMP5-AS1 DOT1L LAMP5 Autophagy MLL leukemia
Online Access:	https://doi.org/10.1186/s40164-024-00488-5