Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting

Dolutegravir’s therapeutic effectiveness in the management of neuroAIDS is mainly limited by its failure to cross the blood–brain barrier. However, lipid-based nanovesicles such as nanoemulsions have demonstrated their potential for the brain targeting of various drugs by intranasal delivery. Thus,...

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發表在:	Gels
Main Authors:	Anroop B. Nair, Sunita Chaudhary, Shery Jacob, Dhwani Patel, Pottathil Shinu, Hiral Shah, Ankit Chaudhary, Bandar Aldhubiab, Rashed M. Almuqbil, Ahmed S. Alnaim, Fatemah Alqattan, Jigar Shah
格式:	Article
語言:	英语
出版:	MDPI AG 2023-02-01
主題:	NeuroAIDS Dolutegravir nanoemulsion nasal in situ gel mucoadhesive brain targeting
在線閱讀:	https://www.mdpi.com/2310-2861/9/2/130