Targeting Mettl14 Using an RNA‐Targeting Clustered Regularly Interspaced Short Palindromic Repeat‐High‐Fidelity Cas13x System Attenuates Doxorubicin‐Induced Cardiotoxicity

Background Doxorubicin is an effective chemotherapy drug used to treat various types of cancer. However, doxorubicin treatment is associated with cardiotoxicity, which limits its clinical use. Exercise can benefit both cancer and cardiovascular disease. Clustered regularly interspaced short palindro...

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Bibliographic Details

Published in:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Main Authors:	Wensi Wan, Caiyue Cui, Yi Zhou, Jiaqi Wang, Xuan Zhao, Xinxin Cui, Jiangpeng Sun, Pujiao Yu, Jingyi Feng, Tianhui Wang, Lijun Wang, Jiahong Xu
Format:	Article
Language:	English
Published:	Wiley 2025-08-01
Subjects:	doxorubicin‐induced cardiotoxicity exercise training high‐fidelity Cas13 Mettl14
Online Access:	https://www.ahajournals.org/doi/10.1161/JAHA.124.040700