Renometabolic disorder in experimental rat model of polycystic ovarian syndrome is reversed by acetate-mediated inhibition of pyruvate dehydrogenase kinase 4

Abstract Background Chronic Kidney disorders is a global public health problem, including in women with polycystic ovarian syndrome (PCOS), and is characterized by renal fibrosis, nephrotoxicity and glomerulonephritis, which increases the possibility of renal failure and organ transplant. Pyruvate d...

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Bibliographic Details

Published in:	BMC Nephrology
Main Authors:	Stephanie E. Areloegbe, Chukwubueze L. Atuma, Ayodeji Aturamu, Isaac O. Ajadi, Oluseyi E. Adelekan, Mary B. Ajadi, Christopher O. Akintayo, Gloria O. Omoruyi, Samuel O. Onyekweli, Omosola F. Anifowose, Oluwatobi A. Amusa, Kayode Ajayi, Paul A. Oyewole, Tolulope E. Adegoke, Kehinde S. Olaniyi
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Subjects:	Acetate Apoptosis PCOS PDK4 Renal disorders
Online Access:	https://doi.org/10.1186/s12882-025-04157-5