Indoleamine 2,3- Dioxygenase: A Novel Immunotherapeutic Target for Osteosarcoma

Introduction: Tumour-emitted molecules induce immunosuppression in the tumour microenvironment. An immunosuppressive enzyme, indoleamine 2,3-dioxygenase (IDO/IDO1), facilitates immune escape in several malignant tumours, including osteosarcoma. Upregulation of IDO establishes a tolerogenic environm...

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Bibliographic Details

Published in:	Journal of Cancer and Allied Specialties
Main Authors:	Asim Farooq, Bilal Zulfiqar, Kashif Asghar
Format:	Article
Language:	English
Published:	Shaukat Khanum Memorial Trust 2022-09-01
Subjects:	Indoleamine 2,3-dioxygenase immunosuppression immunotherapeutic target osteosarcoma
Online Access:	https://journals.sfu.ca/jcas/index.php/jcas/article/view/501