Phylogenetic tree-based amino acid sequence generation for proteomics data analysis of unknown species

In bottom-up proteomics, selecting an appropriate protein amino acid sequence database is vital for reliable peptide identification. However, this approach excludes species with unsequenced genomes, limiting the comprehensiveness. This is a major challenge in current microbiota proteomics, a rapidly...

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Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Nobuaki Miura, Tsuyoshi Tabata, Yasushi Ishihama, Shujiro Okuda
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	Amino acid sequence generation Proteomics data analysis Peptide identification Spectral matching Random branch Ion Cover Score
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037025002041