Novel antibody cocktail therapy targeting extracellular tumor-specific mutations to treat EMT6 cell line-derived triple-negative breast cancer

Abstract Treatment options for triple-negative breast cancer (TNBC) remain limited, and the highly heterogeneous nature of these tumors often contributes to therapeutic resistance. While we have previously demonstrated that antibodies targeting multiple distinct mutated cell surface proteins (MSPs)...

Full description

Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Stephanie C. Pero, Girja S. Shukla, Yujing Sun, Ramiro Barrantes-Reynolds, Colin J. Hartman, Margaret E. Ackerman, Linda Mei, Fan Zhang, Matthew R. Fournier, David N. Krag
Format:	Article
Language:	English
Published:	Nature Portfolio 2026-04-01
Subjects:	Triple-negative breast cancer Mutated cell surface protein-targeting antibodies Somatic missense mutation Antibody-dependent cellular cytotoxicity Tumor growth inhibition
Online Access:	https://doi.org/10.1038/s41598-026-46751-z