EphB2-mediated ephrin-B reverse signaling on microglia drives an anti-viral, but inflammatory and neurotoxic response associated with HIV

Abstract Background Pathological inflammation with a loss of synaptic integrity and function has been implicated in HIV Associated Neurocognitive Disorders (HAND). Although therapeutics exist to increase the lifespan of people living with HIV (PLWH), they are not effective at preventing neuroinflamm...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Jeffrey Koury, Hina Singh, Samantha N. Sutley-Koury, Dominic Fok, Xinru Qiu, Ricky Maung, Benjamin B. Gelman, Iryna M. Ethell, Marcus Kaul
Format:	Article
Language:	English
Published:	BMC 2025-06-01
Subjects:	Neuroinflammation HIV-1 Ephrin-B EphB Interferon-β Neurotoxicity
Online Access:	https://doi.org/10.1186/s12974-025-03481-9