Efficient long-term multilineage engraftment of CD33-edited hematopoietic stem/progenitor cells in nonhuman primates

Current immunotherapeutic targets are often shared between neoplastic and normal hematopoietic stem and progenitor cells (HSPCs), leading to unwanted on-target, off-tumor toxicities. Deletion or modification of such targets to protect normal HSPCs is, therefore, of great interest. Although HSPC modi...

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Bibliographic Details

Published in:	Molecular Therapy: Methods & Clinical Development
Main Authors:	Nicholas E. Petty, Stefan Radtke, Emily Fields, Olivier Humbert, Mallory J. Llewellyn, George S. Laszlo, Haiying Zhu, Keith R. Jerome, Roland B. Walter, Hans-Peter Kiem
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Subjects:	hematopoietic stem cells HSCs gene therapy and editing CRISPR CD33 non-human primate
Online Access:	http://www.sciencedirect.com/science/article/pii/S2329050123001602