Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD.

BACKGROUND: The integrin alphavbeta3 plays an important role in angiogenesis and tumor cell metastasis, and is currently being evaluated as a target for new therapeutic approaches. Several techniques are being studied to enable noninvasive determination of alphavbeta3 expression. We developed [(18)F...

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Published in:	PLoS Medicine
Main Authors:	Roland Haubner, Wolfgang A Weber, Ambros J Beer, Eugenija Vabuliene, Daniel Reim, Mario Sarbia, Karl-Friedrich Becker, Michael Goebel, Rüdiger Hein, Hans-Jürgen Wester, Horst Kessler, Markus Schwaiger
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2005-03-01
Online Access:	http://europepmc.org/articles/PMC1069665?pdf=render