Transient reduction in dendritic spine density in brain-specific profilin1 mutant mice is associated with behavioral deficits

Actin filaments form the backbone of dendritic spines, the postsynaptic compartment of most excitatory synapses in the brain. Spine density changes affect brain function, and postsynaptic actin defects have been implicated in various neuropathies. It is mandatory to identify the actin regulators tha...

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Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	A. Özge Sungur, Caroline Zeitouny, Lea Gabele, Isabell Metz, Markus Wöhr, Kristin Michaelsen-Preusse, Marco B. Rust
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Subjects:	actin dynamics spine morphology memory formation social recognition object recognition ultrasonic vocalization
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2022.952782/full