Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins

ABSTRACT There are many factors that can influence the pharmacokinetics (PK) of a mAb or Fc-fusion molecule with the primary determinant being FcRn-mediated recycling. Through Fab or Fc engineering, IgG-FcRn interaction can be used to generate a variety of therapeutic antibodies with significantly e...

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Bibliographic Details
Published in:Protein & Cell
Main Author: Liming Liu
Format: Article
Language:English
Published: Oxford University Press 2017-04-01
Subjects:
monoclonal antibody (mAb)
Fc-fusion protein
pharmacokinetics
FcRn
target-mediated drug disposition (TMDD)
glycosylation
Online Access:http://link.springer.com/article/10.1007/s13238-017-0408-4

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http://link.springer.com/article/10.1007/s13238-017-0408-4

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