Compound K attenuates hyperglycemia by enhancing glucagon-like peptide-1 secretion through activating TGR5 via the remodeling of gut microbiota and bile acid metabolism

Background: Incretin impairment, characterized by insufficient secretion of L-cell-derived glucagon-like peptide-1 (GLP-1), is a defining step of type 2 diabetes mellitus (T2DM). Ginsenoside compound K (CK) can stimulate GLP-1 secretion; however, the potential mechanism underlying this effect has no...

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الحاوية / القاعدة:	Journal of Ginseng Research
المؤلفون الرئيسيون:	Fengyuan Tian, Shuo Huang, Wangda Xu, Lan Chen, Jianming Su, Haixiang Ni, Xiaohong Feng, Jie Chen, Xi Wang, Qi Huang
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Elsevier 2022-11-01
الموضوعات:	Compound K GLP-1 Bile acids TGR5 Enteroendocrine cells
الوصول للمادة أونلاين:	http://www.sciencedirect.com/science/article/pii/S1226845322000355