Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults

This proof-of-concept study tested if prior BCG revaccination can qualitatively and quantitively enhance antibody and T-cell responses induced by Oxford/AstraZeneca ChAdOx1nCoV-19 or COVISHIELD™, an efficacious and the most widely distributed vaccine in India. We compared COVISHIELD™ induced longitu...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Srabanti Rakshit, Vasista Adiga, Asma Ahmed, Chaitra Parthiban, Nirutha Chetan Kumar, Pratibha Dwarkanath, Sudarshan Shivalingaiah, Srishti Rao, George D’Souza, Mary Dias, Thomas J. A. Maguire, Katie J. Doores, Martijn Zoodsma, Busranur Geckin, Prokar Dasgupta, Sudhir Babji, Krista E. van Meijgaarden, Simone A. Joosten, Tom H. M. Ottenhoff, Yang Li, Mihai G. Netea, Kenneth D. Stuart, Stephen C. De Rosa, M. Juliana McElrath, Annapurna Vyakarnam
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	BCG SARS-CoV-2 T cell antibodies trained immunity
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.985938/full