Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease

Abstract Background The identification of pathogenic mutations in Alzheimer’s disease (AD) causal genes led to a better understanding of the pathobiology of AD. Familial Alzheimer’s disease (FAD) is known to be associated with mutations in the APP, PSEN1, and PSEN2 genes involved in Aβ production; h...

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Bibliographic Details

Published in:	BMC Medicine
Main Authors:	Wenwen Li, Yana Pang, Yan Wang, Fan Mei, Mengmeng Guo, Yiping Wei, Xinyue Li, Wei Qin, Wei Wang, Longfei Jia, Jianping Jia
Format:	Article
Language:	English
Published:	BMC 2023-06-01
Subjects:	ZDHHC21 Palmitoylation Synaptic dysfunction FYN Alzheimer’s disease
Online Access:	https://doi.org/10.1186/s12916-023-02930-7