O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations

Abstract The neurofilament (NF) cytoskeleton is critical for neuronal morphology and function. In particular, the neurofilament-light (NF-L) subunit is required for NF assembly in vivo and is mutated in subtypes of Charcot-Marie-Tooth (CMT) disease. NFs are highly dynamic, and the regulation of NF a...

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الحاوية / القاعدة:	Nature Communications
المؤلفون الرئيسيون:	Duc T. Huynh, Kalina N. Tsolova, Abigail J. Watson, Sai Kwan Khal, Jordan R. Green, Di Li, Jimin Hu, Erik J. Soderblom, Jen-Tsan Chi, Chantell S. Evans, Michael Boyce
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Nature Portfolio 2023-10-01
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41467-023-42227-0