Amifostine reduces inflammation and protects against 5-fluorouracil-induced oral mucositis and hyposalivation

Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) and radiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable. Amifostine is a cytoprotective agent with a described...

Full description

Bibliographic Details

Published in:	Brazilian Journal of Medical and Biological Research
Main Authors:	S.C.M. Barbosa, V.B.M. Pereira, D.V.T. Wong, A.P.M. Santana, L.T. Lucetti, L.L. Carvalho, C.R.N. Barbosa, R.B. Callado, C.A.A. Silva, C.D.H. Lopes, G.A.C. Brito, N.M.N. Alencar, R.C.P. Lima-Júnior
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2019-02-01
Subjects:	Cancer chemotherapy toxicity Oral mucositis 5-Fluorouracil Amifostine Cytokines
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000300601&lng=en&tlng=en