A novel monoclonal antibody generated by immunization with granular tau oligomers binds to tau aggregates at 423-430 amino acid sequence

Abstract Prior to the formation of amyloid fibrils, the pathological hallmark in tau-related neurodegenerative disease, tau monomers aggregate into a diverse range of oligomers. Granular tau oligomers, consisting of approximately 40 tau protein molecules, are present in the prefrontal cortex of pati...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Yoshiyuki Soeda, Emi Hayashi, Naoko Nakatani, Shinsuke Ishigaki, Yuta Takaichi, Taro Tachibana, Yuichi Riku, James K. Chambers, Riki Koike, Moniruzzaman Mohammad, Akihiko Takashima
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-07-01
Subjects:	Tau aggregation Granular tau oligomers Antibody C-terminal regions of tau
Online Access:	https://doi.org/10.1038/s41598-024-65949-7