Identification of an Alternative Glycyrrhizin Metabolite Causing Liquorice-Induced Pseudohyperaldosteronism and the Development of ELISA System to Detect the Predictive Biomarker

Liquorice is usually used as crude drug in traditional Japanese Kampo medicine and traditional Chinese medicine. Liquorice-containing glycyrrhizin (GL) can cause pseudohyperaldosteronism as a side effect. Previously, we identified 18β-glycyrrhetyl-3-O-sulfate (3) as a GL metabolite in Eisai hyperbil...

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Published in:	Frontiers in Pharmacology
Main Authors:	Kan'ichiro Ishiuchi, Osamu Morinaga, Tetsuhiro Yoshino, Miaki Mitamura, Asuka Hirasawa, Yasuhito Maki, Yuuna Tashita, Tsubasa Kondo, Kakuyou Ogawa, Fangyi Lian, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Takao Namiki, Masaru Mimura, Kenji Watanabe, Toshiaki Makino
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-05-01
Subjects:	kampo medicine side effect liquorice glycyrrhizin pseudoaldosteronism sex differences
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.688508/full