Transferrin Receptor‐Mediated Iron Uptake Promotes Colon Tumorigenesis

Abstract Transferrin receptor (TFRC) is the major mediator for iron entry into a cell. Under excessive iron conditions, TFRC is expected to be reduced to lower iron uptake and toxicity. However, the mechanism whereby TFRC expression is maintained at high levels in iron‐enriched cancer cells and the...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Hyeoncheol Kim, Luke B Villareal, Zhaoli Liu, Mohammad Haneef, Daniel M Falcon, David R Martin, Ho‐Joon Lee, Michael K Dame, Durga Attili, Ying Chen, James Varani, Jason R. Spence, Olga Kovbasnjuk, Justin A Colacino, Costas A. Lyssiotis, Henry C Lin, Yatrik M Shah, Xiang Xue
Format:	Article
Language:	English
Published:	Wiley 2023-04-01
Subjects:	colon DNA damage response iron TFRC β‐catenin
Online Access:	https://doi.org/10.1002/advs.202207693