Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling

Osteoarthritis (OA), in which M1 macrophage polarization in the synovium exacerbates disease progression, is a major cause of cartilage degeneration and functional disabilities. Therapeutic strategies of OA designed to interfere with the polarization of macrophages have rarely been reported. Here, w...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Ziying Sun, Qianqian Liu, Zhongyang Lv, Jiawei Li, Xingquan Xu, Heng Sun, Maochun Wang, Kuoyang Sun, Tianshu Shi, Zizheng Liu, Guihua Tan, Wenqiang Yan, Rui Wu, Yannick Xiaofan Yang, Shiro Ikegawa, Qing Jiang, Yang Sun, Dongquan Shi
Format:	Article
Language:	English
Published:	Elsevier 2022-07-01
Subjects:	SHP2 SHP099 Osteoarthritis Synovitis Toll-like receptor signaling Macrophage
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383522000600