Prediction of drug-drug interactions in clozapine combination therapy based on physiologically based pharmacokinetic model

Objective·To develop physiologically based pharmacokinetic (PBPK) models specifically designed for the Chinese population by utilizing the combination of clozapine and fluvoxamine as a case, and predict the drug-drug interaction (DDI) associated with the combination medication of clozapine, ultimate...

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Bibliographic Details

Published in:	Shanghai Jiaotong Daxue xuebao. Yixue ban
Main Authors:	MOU Fan, HUANG Zhiwei, CHENG Yu, ZHAO Xue, LI Huafang, YU Shunying
Format:	Article
Language:	Chinese
Published:	Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) 2024-11-01
Subjects:	clozapine combination medication drug-drug interaction physiologically based pharmacokinetic model
Online Access:	https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-11-1414.shtml