Descending serotonergic modulation from rostral ventromedial medulla to spinal trigeminal nucleus is involved in experimental occlusal interference-induced chronic orofacial hyperalgesia

Abstract Background Dental treatment associated with unadaptable occlusal alteration can cause chronic primary myofascial orofacial pain. The serotonin (5-HT) pathway from the rostral ventromedial medulla (RVM) exerts descending modulation on nociceptive transmission in the spinal trigeminal nucleus...

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Bibliographic Details

Published in:	The Journal of Headache and Pain
Main Authors:	Si-Yi Mo, Yang Xue, Yuan Li, Yao-Jun Zhang, Xiao-Xiang Xu, Kai-Yuan Fu, Barry J. Sessle, Qiu-Fei Xie, Ye Cao
Format:	Article
Language:	English
Published:	BMC 2023-05-01
Subjects:	Pain modulation Serotonin Rostral ventromedial medulla Chronic primary myofascial orofacial pain Experimental occlusal interference Hyperalgesia
Online Access:	https://doi.org/10.1186/s10194-023-01584-3