PLPP/CIN-mediated NF2 S10 dephosphorylation distinctly regulates kainate-induced seizure susceptibility and neuronal death through PAK1-NF-κB-COX-2-PTGES2 signaling pathway

Abstract Background Pyridoxal-5′-phosphate phosphatase/chronophin (PLPP/CIN) selectively dephosphorylates serine (S) 10 site on neurofibromin 2 (NF2, also known as merlin (moesin-ezrin-radixin-like protein) or schwannomin). p21-activated kinase 1 (PAK1) is a serine/threonine protein kinase, which is...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Ji-Eun Kim, Duk-Shin Lee, Tae-Hyun Kim, Hana Park, Min-Ju Kim, Tae-Cheon Kang
Format:	Article
Language:	English
Published:	BMC 2023-04-01
Subjects:	COX-2 IPA-3 Merlin NF-κB NF2 PAK1
Online Access:	https://doi.org/10.1186/s12974-023-02788-9